Mfg Part Number
Ab02979-10.3
Vector Labs Ab02979-10.3 Anti-Phospho-Tau [pT231/pS235_1], Human IgG1, Fc Silent™, lambda (200 μg)
Quick Overview
Vector Labs Ab02979-10.3 Anti-Phospho-Tau [pT231/pS235_1], Human IgG1, Fc Silent™, lambda (200 μg)
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | pT231/pS235_1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | MAPT; TAU; PHF-tau; PHF; MAPTL; MTBT1; Tau proteins; Phospho-Tau (pT231/pS235); Microtubule‐associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; SPR; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Chicken scFv format for improved compatibility with existing reagents, assays, and techniques. |
| Specificity Statement: | This antibody shows binding affinity towards pT231/pS235 peptide of the human tau protein. The binding affinity and specificity of this antibody relied heavily on the phosphorylation at Thr-231. |
| Application Notes: | ELISA was used for the screening of positive clones that bind phosphopeptides. The binding affinity of the IgG antibody towards pT231/pS235 phosphopeptide was found to be Kd = 0.35 nM using surface plasmon resonance. This antibody can recognize the phospho-tau epitopes in full-length human tau. This antibody was also used for the immunohistochemical analysis of the human brain with Alzheimer's disease (PMID: 23148212). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |