Mfg Part Number
Ab02980-3.3
Vector Labs Ab02980-3.3 Anti-Mesothelin [MOR06626], Mouse IgG2b, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was isolated from a synthetic phage display library (HuCAL®) after 3 rounds of panning against whole CHO-A9 and NCI-H226 cells expressing mesothelin.
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| Product Class: | Purified |
|---|---|
| Clone ID: | MOR06626 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | MSLN; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds the human and murine mesothelin. Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. Because of its limited expression in normal tissues and overexpression in tumors, mesothelin is a promising candidate for tumor-specific therapy. |
| Application Notes: | The binding reactivity of the Fab version of this antibody towards human and murine mesothelin was done using ELISA. The Fab version of this antibody binds human and murine meosthelin with a binding affinity of Kd= 6.7 × 10−10 and Kd= 6.7 × 10−9 (US9023351). The IgG1 version of this antibody was used to detect mesothelin on NCI-H226 cells by flow cytometry (US9023351). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |