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Mfg Part Number

Ab03041-30.11-BS

Vector Labs Ab03041-30.11-BS Anti-Cn2 toxin [6009F], scFv fragment (His), ScFv, (1 mg)

VECTOR LABS

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Quick Overview

The original antibody was isolated from a human non-immune phage display library by panning the library against Cn2 toxin of scorpion Centruroides noxius.

$4,938.70

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Description

Product Class: Purified
Clone ID: 6009F
Heavy Chain Modification: ScFv
Synonyms: scorpion toxin; Beta-mammal toxin Cn2; Toxin 2; Toxin II.9.2.2; scorpion venom
Amount: 1 mg
Application Codes Clone: ELISA; neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS only.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody binds the mammal-specific Cn2 toxin found in the venom produced by Centruroides noxius Hoffmann (Mexican scorpion). This antibody binds an epitope on the Cn2 toxin that is different from the binding epitope of another anti-Cn2 toxin antibody BCF2. It was also reported that this antibody cross-reacts with other toxins like Cn3, Css2, and Css4 . Cross-reactivity against Css2 was relevant, because this toxin is the major constituent of the venom of Centruroides suffusus (PMID: 21156801).
Application Notes: The binding specificity and characterization of this antibody towards Cn2 toxin of scorpion Centruroicles noxius was tested using ELISA. The epitope mapping of this antibody was performed using competitive ELISA. The scFv version of this antibody binds Cn2 toxin with an affinity of 410pM and capable of neutralizing 2 LD50 of Cn2 toxin when a 1 : 10 molar ratio of toxin-to-antibody fragment was used. It was also able to neutralize 2 LD50 of the whole venom (PMID: 15885107; US7381802). ELISA was also used to determine the cross- reactivity of this antibody towards other toxins like Cn3, Css2, and Css4 (PMID: 21156801).

Product Class:	Purified
Clone ID:	6009F
Heavy Chain Modification:	ScFv
Synonyms:	scorpion toxin; Beta-mammal toxin Cn2; Toxin 2; Toxin II.9.2.2; scorpion venom
Amount:	1 mg
Application Codes Clone:	ELISA; neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS only.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody binds the mammal-specific Cn2 toxin found in the venom produced by Centruroides noxius Hoffmann (Mexican scorpion). This antibody binds an epitope on the Cn2 toxin that is different from the binding epitope of another anti-Cn2 toxin antibody BCF2. It was also reported that this antibody cross-reacts with other toxins like Cn3, Css2, and Css4 . Cross-reactivity against Css2 was relevant, because this toxin is the major constituent of the venom of Centruroides suffusus (PMID: 21156801).
Application Notes:	The binding specificity and characterization of this antibody towards Cn2 toxin of scorpion Centruroicles noxius was tested using ELISA. The epitope mapping of this antibody was performed using competitive ELISA. The scFv version of this antibody binds Cn2 toxin with an affinity of 410pM and capable of neutralizing 2 LD50 of Cn2 toxin when a 1 : 10 molar ratio of toxin-to-antibody fragment was used. It was also able to neutralize 2 LD50 of the whole venom (PMID: 15885107; US7381802). ELISA was also used to determine the cross- reactivity of this antibody towards other toxins like Cn3, Css2, and Css4 (PMID: 21156801).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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