Mfg Part Number
Ab03044-10.3
Vector Labs Ab03044-10.3 Anti-IL-6R [AUK12-20], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing female BALB/c mice with 10 .mu.g/mouse of the soluble IL-6R (SR 344) immunogen in Freund's complete adjuvant.
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| Product Class: | Purified |
|---|---|
| Clone ID: | AUK12-20 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD126 |
| Amount: | 200 μg |
| Application Codes Clone: | Inhibit; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody binds the human IL-6 receptor at a site that is different from the epitope recognized by Tocilizumab (PM-1). The presence of this antibody inhibits the binding of IL-6 to the human IL-6R. |
| Application Notes: | This antibody can be used to inhibit the binding of IL-6 to its receptor IL-6R. It is also reported to inhibit IL-6 functions. The binding characterization of this antibody was done using ELISA (US5795965). This antibody was also reported to inhibit IL-6 dependent tumor cell growth (PMID: 8152440). This antibody was used in a study wherein the combined effect of antigrowth factor receptor antibodies was tested on growth limitation of myeloma cells (PMID: 8120920). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |