Vector Labs Ab03051-10.0 Anti-CD7 [T3-3A1], Human IgG1, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: T3-3A1
Synonyms: GP40; TP41; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9 ; T3.3A1; 3A1
Amount: 200 μg
Application Codes Clone: ELISA; IP; FC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds human CD7. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. CD7 is useful in the identification of precursor T cells as well as an important marker for the identification of leukemic T cells.
Application Notes: This antibody is capable of recognizing CD7 antigen present on various T cell lines like n HSB-2, HPB-MLT, MOLT-4, CEM, and TALL-1. This antibody also bound a majority (85%) of human PB E-rosette-positive cells. Immunoprecipitation of an HSB-2 extract with this antibody yielded one specific band with a molecular weight of approximately 40,000 in the presence of reducing agent (PMID: 6156457). This antibody was also used in the development of a cell ELISA to monitor the PHA-induced expression of the CD7 antigen in fixed mononuclear leukocytes (PMID: 3492562). This antibody was also used in combination with another anti-CD7 antibody mab 69 of development of a sandwich ELISA for detection of solubilized CD7 antigen (PMID: 2464646). This antibody was used in a study relating to identifying CD7 as target structure for T-cell imaging. Noninvasive CD7 immuno-imaging is a promising strategy to track T-cell responses in the context of diverse immunotherapies in vivo with additional theragnostic potential in T-cell-mediated diseases (PMID: 30613283).

Product Class:	Purified
Clone ID:	T3-3A1
Synonyms:	GP40; TP41; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9 ; T3.3A1; 3A1
Amount:	200 μg
Application Codes Clone:	ELISA; IP; FC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds human CD7. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. CD7 is useful in the identification of precursor T cells as well as an important marker for the identification of leukemic T cells.
Application Notes:	This antibody is capable of recognizing CD7 antigen present on various T cell lines like n HSB-2, HPB-MLT, MOLT-4, CEM, and TALL-1. This antibody also bound a majority (85%) of human PB E-rosette-positive cells. Immunoprecipitation of an HSB-2 extract with this antibody yielded one specific band with a molecular weight of approximately 40,000 in the presence of reducing agent (PMID: 6156457). This antibody was also used in the development of a cell ELISA to monitor the PHA-induced expression of the CD7 antigen in fixed mononuclear leukocytes (PMID: 3492562). This antibody was also used in combination with another anti-CD7 antibody mab 69 of development of a sandwich ELISA for detection of solubilized CD7 antigen (PMID: 2464646). This antibody was used in a study relating to identifying CD7 as target structure for T-cell imaging. Noninvasive CD7 immuno-imaging is a promising strategy to track T-cell responses in the context of diverse immunotherapies in vivo with additional theragnostic potential in T-cell-mediated diseases (PMID: 30613283).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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