Mfg Part Number
Ab03090-23.0
Vector Labs Ab03090-23.0 Anti-Myelin basic protein [F28C4], Rabbit IgG, lambda (200 μg)
Quick Overview
The original antibody was generated by immunizing PL/J mice with MBP acetyl residues 1-9.
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| Product Class: | Purified |
|---|---|
| Clone ID: | F28C4 |
| Synonyms: | MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody binds human myelin basic protein (MBP), acetyl residues 1-9 (ASQKRPSQR). The MBP isoforms 4 and 14 along with PLP are most abundant protein components of the myelin membrane in the CNS. The smaller isoforms are believed to have an important role in remyelination of denuded axons in multiple sclerosis. |
| Application Notes: | This antibody shares a cross reactive idiotpe with the TCRs, possibly as a result of having similar fine epitope specificity and sequence homology (PMID: 7517973). This antibody can be used for the detection of MBP in a solution using ELISA (PMID: 8567971). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |