Mfg Part Number
Ab03095-10.0
Vector Labs Ab03095-10.0 Anti-Myelin basic protein [B5V6], Human IgG1, lambda (200 μg)
Quick Overview
The original antibody was isolated from a phage display library of single-chain variable fragments (scFvs), which was constructed from blood lymphocytes of patienst with MS as a potential source of representative MS autoantibodies.
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| Product Class: | Purified |
|---|---|
| Clone ID: | B5V6 |
| Synonyms: | MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody binds bovine myelin binding protein (MBP) both in its native and denatured form in the region between amino acids 130–156. The MBP isoforms 4 and 14 along with PLP are most abundant protein components of the myelin membrane in the CNS. The smaller isoforms are believed to have an important role in remyelination of denuded axons in multiple sclerosis. |
| Application Notes: | The scFv version of this antibody binds bovine myelin basic protein with a binding affinity of 12 nM in an ELISA (PMID: 21859892). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |