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Mfg Part Number

Ab03140-10.0

Vector Labs Ab03140-10.0 Anti-TIGIT [AET2010], Human IgG1, lambda (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was isolated from a fully synthetic human single chain antibody phage display library by multiple rounds of bio panning against human TIGIT.

$517.40

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Description

Product Class: Purified
Clone ID: AET2010
Synonyms: VSTM3; VSIG9; WUCAM; T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3
Amount: 200 μg
Application Codes Clone: ELISA; FC; Block
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody binds the human TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a type I transmembrane protein that is a member of the CD28 family within the Ig superfamily of proteins. It is an immune receptor present on some T cells and natural killer cells (NK). It binds the poliovirus receptor (PVR) with high affinity which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Application Notes: The binding characterization of this antibody for TIGIT was done using ELISA. The IgG1 version of this antibody binds human TIGIT with a binding affinity of Kd= 3.74 nM. This antibody is also capable of blocking the binding of TIGIT to its ligand CD155. The binding of this antibody to membrane bound TIGIT was determined using flow cytometry. The anti-tumor activity of this antibody was tested against NK-92MI cells in vitro. It was also reported that AET 2010 exhibits enhanced anti-tumor activity in the CDX mouse model of NK-92MI cells (CN112679610).

Product Class:	Purified
Clone ID:	AET2010
Synonyms:	VSTM3; VSIG9; WUCAM; T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3
Amount:	200 μg
Application Codes Clone:	ELISA; FC; Block
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody binds the human TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a type I transmembrane protein that is a member of the CD28 family within the Ig superfamily of proteins. It is an immune receptor present on some T cells and natural killer cells (NK). It binds the poliovirus receptor (PVR) with high affinity which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Application Notes:	The binding characterization of this antibody for TIGIT was done using ELISA. The IgG1 version of this antibody binds human TIGIT with a binding affinity of Kd= 3.74 nM. This antibody is also capable of blocking the binding of TIGIT to its ligand CD155. The binding of this antibody to membrane bound TIGIT was determined using flow cytometry. The anti-tumor activity of this antibody was tested against NK-92MI cells in vitro. It was also reported that AET 2010 exhibits enhanced anti-tumor activity in the CDX mouse model of NK-92MI cells (CN112679610).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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