Mfg Part Number
Ab03146-2.3
Vector Labs Ab03146-2.3 Anti-PD-1 [11F5C5], Mouse IgG2a, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with recombinant human PD-1 protein comprising amino acids 32-160.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 11F5C5 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD279; PD1; PD 1; hPD-1; PDCD1; Programmed cell death protein 1; Programmed cell death 1; Protein PD-1; CGMCC NO.16209; NAT105 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; WB; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds the extracellular domain of the human PD-1. PD-1 is an immunosuppressive receptor having a molecular weight of 50 to 55 kD, a type 1 transmembrane glycoprotein belonging to immunoglobulin CD28 / CTLA-4 family members. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. It delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. |
| Application Notes: | This antibody is highly similar to the commercially available anti-PD-1 antibody NAT105. The binding specificity of this antibody towards human PD-1 was determined using ELISA. The original IgG2a antibody binds human PD_1 with an affinity constant of 7.13X10^9 M^(-1). This antibody is capable of detecting human PD-1 in a western blot assay. This antibody was used in the immunohistochemical staining of samples of T cell lymphomas and B cell lymphomas (CN109293775). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |