Vector Labs Ab03148-2.0 Anti-p53 [70237-85], Mouse IgG2a, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 70237-85
Synonyms: Tp53; cellular tumor antigen p53; antigen NY-CO-13; phosphoprotein p53; tumor suppressor p53; D0-7; DO-7
Amount: 200 μg
Application Codes Clone: ELISA; WB; IHC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2a
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody bind p53. It acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. When damaged cells cannot be repaired, P53 protein will participate in the process of cell apoptosis. Cells with P53 protein defects will lose this control and even continue to divide under adverse conditions.
Application Notes: This antibody is highly similar to the commercially available anti-p53 antibody DO-7. The binding specificity and affinity of this antibody for human p53 was detected using ELISA. The original IgG2a version of this antibody binds p53 with a binding affinity constant of 3.02 X 10^9 M^(-1). Western blotting experiments carried out with this antibody show that it can specifically recognize recombinant p53 protein and Jurkat cell line expressing P53 protein. This antibody can also be used in the detection of p53 in a variety of cancerous tissues including esophageal squamous cell carcinoma, gastric adenocarcinoma, intestinal adenocarcinoma, cervical squamous cell carcinoma, hemangioma, and fibrosarcoma. This antibody was also used in the immunohistochemical analysis of p53 in ovarian serous papillary carcinoma tissue (CN105112377).

Product Class:	Purified
Clone ID:	70237-85
Synonyms:	Tp53; cellular tumor antigen p53; antigen NY-CO-13; phosphoprotein p53; tumor suppressor p53; D0-7; DO-7
Amount:	200 μg
Application Codes Clone:	ELISA; WB; IHC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2a
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody bind p53. It acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. When damaged cells cannot be repaired, P53 protein will participate in the process of cell apoptosis. Cells with P53 protein defects will lose this control and even continue to divide under adverse conditions.
Application Notes:	This antibody is highly similar to the commercially available anti-p53 antibody DO-7. The binding specificity and affinity of this antibody for human p53 was detected using ELISA. The original IgG2a version of this antibody binds p53 with a binding affinity constant of 3.02 X 10^9 M^(-1). Western blotting experiments carried out with this antibody show that it can specifically recognize recombinant p53 protein and Jurkat cell line expressing P53 protein. This antibody can also be used in the detection of p53 in a variety of cancerous tissues including esophageal squamous cell carcinoma, gastric adenocarcinoma, intestinal adenocarcinoma, cervical squamous cell carcinoma, hemangioma, and fibrosarcoma. This antibody was also used in the immunohistochemical analysis of p53 in ovarian serous papillary carcinoma tissue (CN105112377).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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