Mfg Part Number
Ab03152-15.0
Vector Labs Ab03152-15.0 Anti-Carcinoma surface antigen [CR4E8], Human IgM, lambda (50 μg)
Quick Overview
The original antibody was generated by fusing SPAZ4 cells with peripheral blood lymphocytes from a patient with cervical cancer, who was immunized intralymphatically with a viral oncolysate allogeneic tumor vaccine.
$692.90
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| Product Class: | Purified |
|---|---|
| Clone ID: | CR4E8 |
| Synonyms: | cancerous cells |
| Amount: | 50 μg |
| Application Codes Clone: | WB; IF; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgM |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody can recognize antigens expressed on the cell surface of human ovarian, cervix, breast, colon, melanoma and other carcinomas. This antibody does not react with normal human tissues. The epitope recognized by this antibody is different from the one recognized by another similar antibody AC6C3. |
| Application Notes: | This antibody reacted with lysates of the SW756 cervical carcinoma line in western blotting assay. Cell surface immunofluorescence determinations using the fluorescence activated cell sorter revealed that this antibody stain ovarian or cervix carcinoma tumor cell lines (PMID: 7756578). Intralesional administration of indium-111 (111In) or yttrium-90 (90Y) labelled IgM antibody in mice with subcutaneous human head and neck squamous cell carcinoma nodules resulted in prolonged high tumor radioactivity with little normal tissue uptake, with kidney and liver having the highest values (PMID: 9380829). Intralesional administration of 90Y-labeled IgM in nude mice bearing subcutaneous human head and neck squamous cell carcinoma xenografts can ablate tumors with modest acute or late toxicity (PMID: 15068610). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |