Mfg Part Number
Ab03166-23.0
Vector Labs Ab03166-23.0 Anti-CD3 [CD3B219], Rabbit IgG, lambda (200 μg)
Quick Overview
Vector Labs Ab03166-23.0 Anti-CD3 [CD3B219], Rabbit IgG, lambda (200 μg)
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | CD3B219 |
| Synonyms: | T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e; SP34-2 |
| Amount: | 200 μg |
| Application Codes Clone: | FC; in vitro |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG4 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | The antibody is specific for CD3 epsilon. |
| Application Notes: | The antibody was used to construct different CD33 xCD3 bispecific antibodies (IgG4). In vitro T cell mediated cytotoxicity assays were performed using the bispecific antibody and the cytotoxicity was measured by flow cytometry. Ex vivo cytotoxicity assay showed the paired antibody promoted a dose-dependent reduction of total cytotoxicity that correlated with T cell activation after 48 hours (US20210040209A1). The antibody is considered a high affinity binder (Kd= 8mM) (US20210214440A1). The CD33×CD3 bispecific antibodies specifically induce cell cytotoxicity of MOLM-13 cells and CD33+ monocytes at 48 hr (US20200048349A1). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |