Mfg Part Number
Ab03167-3.0
Vector Labs Ab03167-3.0 Anti-CD47 [C47B227], Mouse IgG2b, kappa (100 μg)
Quick Overview
Three de novo phage libraries displaying Fab variants on phage coat protein pIX were panned against biotinylated human CD47.
$570.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | C47B227 |
| Synonyms: | IAP; MER6; OV-3; Leukocyte surface antigen CD47; Antigenic surface determinant protein OA3; Integrin-associated protein; Protein MER6; ovarian cancer marker |
| Amount: | 100 μg |
| Application Codes Clone: | Crystallography; Inhibition |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific for CD47. The antibody binds a conformational epitope composed of residues in the C’C’’ loop (L54) and B-strand C*’ (K56 and T58) regions. |
| Application Notes: | The structure of the Fab fragment in complex with CD47 was determined. The binding affinity of the antibody to human and cyno CD47 were measured (Kd= 1nM and 0,5 nM respectively). The antibody inhibited CD47 from interacting with SIRP alpha (US10864268). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |