Mfg Part Number
Ab03181-1.1
Vector Labs Ab03181-1.1 Anti-Cytokeratin 17 [D1-1B2], Mouse IgG1, kappa (200 μg)
Quick Overview
The original antibody was isolate from a human-derived scFv phage display library by panning CK17-D1 peptide (amino acids 79-432 of human cytokeratin 17).
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| Product Class: | Purified |
|---|---|
| Clone ID: | D1-1B2 |
| Synonyms: | CK17; CK-17; KRT17; K17; Keratin; type I cytoskeletal 17; Cytokeratin-17; Keratin-17 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length chimeric mouse antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody is specific for amino acids 79-432 of human cytokeratin 17. Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 17 regulates the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). |
| Application Notes: | The binding characterization of the scFv antibody was done by ELISA. The binding specificity of the IgG1 version of this antibody for human cytokeratin 17 was determined using flow cytometry (WO2010126279). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |