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Mfg Part Number

Ab03185-23.0

Vector Labs Ab03185-23.0 Anti-Cytokeratin 18 [HH156], Rabbit IgG, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with human cytokeratin 18 extracellular domain polypeptide 'LEDGEDFNLGDALD'. Later on the humanized version of this antibody was generated by grafting the CDRs of the original mouse antibody E156 onto human framework regions.

$517.40

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Description

Product Class: Purified
Clone ID: HH156
Synonyms: CK18; CK-18; CK 18; KRT18; CYK18; Keratin type I cytoskeletal 18; Cytokeratin-18; Cell proliferation-inducing gene 46 protein
Amount: 200 μg
Application Codes Clone: ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody is specific for extracellular domain of the human cytokeratin 18 containing amino acids 'LEDGEDFNLGDALD'. Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 18 is widely expressed in human monolayer epithelial tissues, and generally appears in pairs with CK8. CK18 is a serum marker for a variety of tumor diagnosis, as well as a serum marker for liver injury. It is involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, it plays a role in filament reorganization. It is also involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Application Notes: This antibody can bind human cytokeratin 18 in an ELISA. The original IgG1 version of this antibody is reported to bind human cytokeratin 18 with a binding affinity of 32.8 pM.

Product Class:	Purified
Clone ID:	HH156
Synonyms:	CK18; CK-18; CK 18; KRT18; CYK18; Keratin type I cytoskeletal 18; Cytokeratin-18; Cell proliferation-inducing gene 46 protein
Amount:	200 μg
Application Codes Clone:	ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody is specific for extracellular domain of the human cytokeratin 18 containing amino acids 'LEDGEDFNLGDALD'. Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 18 is widely expressed in human monolayer epithelial tissues, and generally appears in pairs with CK8. CK18 is a serum marker for a variety of tumor diagnosis, as well as a serum marker for liver injury. It is involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, it plays a role in filament reorganization. It is also involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Application Notes:	This antibody can bind human cytokeratin 18 in an ELISA. The original IgG1 version of this antibody is reported to bind human cytokeratin 18 with a binding affinity of 32.8 pM.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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