Mfg Part Number
Ab03193-1.1
Vector Labs Ab03193-1.1 Anti-B-catenin [3B1D11A8], Mouse IgG1, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with human beta-catenin-KLH conjugate in Freund's non-complete adjuvant.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 3B1D11A8 |
| Synonyms: | CTNNB1; CTNNB; Catenin beta-1; Beta-catenin; CAT-5H10; CGMCC No. 19685 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds human beta-catenin. The human β-catenin acts as a multi-functional protein that plays a very important role in cell adhesion and Wnt signaling pathway mediated gene expression regulation. Β-catenin on the cell membrane can be combined with the cytoplasmic domain of E-Cadherin (E-CAD) to form an e-cadherin / β-catenin complex, which mediates mutual adhesion between the same type. It acts as a key regulatory molecule in the Wnt signaling pathway and plays an important role in the occurrence / evolution of the embryonic development and tumor. |
| Application Notes: | The binding characterization of this antibody was done using ELISA. The original mouse IgG1 antibody binds human B-catenin with an affinity constant of 4.96 X 10^(9) M^(-1). This antibody was also used in the immunohistochemical analysis of colorectal carcinoma and pancreatic cancer tissues. The immunohistochemical staining pattern of this antibody is similar to commercially available antibody CAT-5H10 (CN112457400). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |