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Mfg Part Number

Ab03193-23.0

Vector Labs Ab03193-23.0 Anti-B-catenin [3B1D11A8], Rabbit IgG, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with human beta-catenin-KLH conjugate in Freund's non-complete adjuvant.

$517.40

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Description

Product Class: Purified
Clone ID: 3B1D11A8
Synonyms: CTNNB1; CTNNB; Catenin beta-1; Beta-catenin; CAT-5H10; CGMCC No. 19685
Amount: 200 μg
Application Codes Clone: ELISA; IHC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds human beta-catenin. The human β-catenin acts as a multi-functional protein that plays a very important role in cell adhesion and Wnt signaling pathway mediated gene expression regulation. Β-catenin on the cell membrane can be combined with the cytoplasmic domain of E-Cadherin (E-CAD) to form an e-cadherin / β-catenin complex, which mediates mutual adhesion between the same type. It acts as a key regulatory molecule in the Wnt signaling pathway and plays an important role in the occurrence / evolution of the embryonic development and tumor.
Application Notes: The binding characterization of this antibody was done using ELISA. The original mouse IgG1 antibody binds human B-catenin with an affinity constant of 4.96 X 10^(9) M^(-1). This antibody was also used in the immunohistochemical analysis of colorectal carcinoma and pancreatic cancer tissues. The immunohistochemical staining pattern of this antibody is similar to commercially available antibody CAT-5H10 (CN112457400).

Product Class:	Purified
Clone ID:	3B1D11A8
Synonyms:	CTNNB1; CTNNB; Catenin beta-1; Beta-catenin; CAT-5H10; CGMCC No. 19685
Amount:	200 μg
Application Codes Clone:	ELISA; IHC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds human beta-catenin. The human β-catenin acts as a multi-functional protein that plays a very important role in cell adhesion and Wnt signaling pathway mediated gene expression regulation. Β-catenin on the cell membrane can be combined with the cytoplasmic domain of E-Cadherin (E-CAD) to form an e-cadherin / β-catenin complex, which mediates mutual adhesion between the same type. It acts as a key regulatory molecule in the Wnt signaling pathway and plays an important role in the occurrence / evolution of the embryonic development and tumor.
Application Notes:	The binding characterization of this antibody was done using ELISA. The original mouse IgG1 antibody binds human B-catenin with an affinity constant of 4.96 X 10^(9) M^(-1). This antibody was also used in the immunohistochemical analysis of colorectal carcinoma and pancreatic cancer tissues. The immunohistochemical staining pattern of this antibody is similar to commercially available antibody CAT-5H10 (CN112457400).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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