JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Skip to the beginning of the images gallery

Mfg Part Number

Ab03194-1.159

Vector Labs Ab03194-1.159 Anti-Rotavirus [2B10 (ARP1; VHH1)], Mouse IgG1-Fc Fusion, (100 μg)

VECTOR LABS

Be the first to review this product

Quick Overview

The original antibody was generated by immunizing a llama subcutaneously and intramuscularly with 5×10^12 pfu of Rhesus rotavirus strain RRV (serotype G3).

$692.90

Order will ship within 1-3 business days

Description

Product Class: Purified
Clone ID: 2B10 (ARP1; VHH1)
Synonyms: RRV; Outer capsid glycoprotein;
Amount: 100 μg
Application Codes Clone: ELISA; neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: VHH
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original VHH format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds antigens expressed on rotavirus particles. Rotaviruses are the most common cause of infantile diarrhea in the world and most children get infected during the first 5 years of life.
Application Notes: This antibody is capable of binding rotavirus particles present in serum samples in an ELISA. This antibody was capable of reducing the morbidity of rotavirus induced diarrhea in vivo in mice (PMID: 16616802). This antibody is capable of neutralizing rotavirus in vitro and in vivo (PMID: 17083044). This antibody is capable of neutralizing CK5 strain of rotavirus in an in vitro plaque assay with an IC50 of approximately 3 nM. Daily oral administration of 50 or 100µg 2B10 nanobody could either prevent diarrhea or reduce the number of days with diarrhea per mouse pup model (PMID: 21939690). The mouse IgG1 Fc-fusion version of this antibody confers significantly increased protection against rotavirus in a neonatal mouse model of rotavirus-induced diarrhea by reducing the prevalence, duration and severity of diarrhea and the viral load in the small intestines (PMID: 27439689).

Product Class:	Purified
Clone ID:	2B10 (ARP1; VHH1)
Synonyms:	RRV; Outer capsid glycoprotein;
Amount:	100 μg
Application Codes Clone:	ELISA; neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	VHH
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric mouse antibody was made using the variable domain sequences of the original VHH format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds antigens expressed on rotavirus particles. Rotaviruses are the most common cause of infantile diarrhea in the world and most children get infected during the first 5 years of life.
Application Notes:	This antibody is capable of binding rotavirus particles present in serum samples in an ELISA. This antibody was capable of reducing the morbidity of rotavirus induced diarrhea in vivo in mice (PMID: 16616802). This antibody is capable of neutralizing rotavirus in vitro and in vivo (PMID: 17083044). This antibody is capable of neutralizing CK5 strain of rotavirus in an in vitro plaque assay with an IC50 of approximately 3 nM. Daily oral administration of 50 or 100µg 2B10 nanobody could either prevent diarrhea or reduce the number of days with diarrhea per mouse pup model (PMID: 21939690). The mouse IgG1 Fc-fusion version of this antibody confers significantly increased protection against rotavirus in a neonatal mouse model of rotavirus-induced diarrhea by reducing the prevalence, duration and severity of diarrhea and the viral load in the small intestines (PMID: 27439689).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

Reviews