Mfg Part Number
Ab03205-23.0
Vector Labs Ab03205-23.0 Anti-E Cadherin [56-4], Rabbit IgG, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing rabbits with purified extracellular domain of mouse E-cadherin.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 56-4 |
| Synonyms: | CD324; ARC-1; Cdh1; Cadherin-1; Cadherin E; E-Cadherin; Uvomorulin |
| Amount: | 200 μg |
| Application Codes Clone: | agonist; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds mouse E-cadherin. Cadherins are calcium-dependent cell adhesion proteins. It is localized on the surfaces of epithelial cells in regions of cell-cell contact known as adherens junctions. E-cadherins are reported to play an important role in cancer metastasis. |
| Application Notes: | The binding of this antibody to mouse E-cadherin results in its activation. The initial binding characterization of this antibody to mouse E-cadherin was done using ELISA. This antibody was used to study the effect of activation of mouse E-cadherin on the growth and metastasis of a spontaneous breast cancer mouse model. Female MMTV-PyMT and control mice treated with 5 mg/kg of this antibody developed tumors in all 10 mammary glands. Also the number of metastasis nodules was significantly reduced with treatment with 56-4 activating antibody (PMID: 32127478; WO2020243616). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |