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Mfg Part Number

Ab03209-1.159

Vector Labs Ab03209-1.159 Anti-IL-13 [DOM10-53-616], Mouse IgG1-Fc Fusion, (100 μg)

VECTOR LABS

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Quick Overview

The original antibody DOM10-53-546 was isolated from in-line fusion libraries selected against human IL-13. This antibody (DOM10-53-616) was generated by replacing the CDR2 of DOM10-53-546 with that of DOM10-53-386.

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Description

Product Class: Purified
Clone ID: DOM10-53-616
Synonyms: IL13; NC30; Interleukin-13; DOM10-53-546; DOM10-53-386
Amount: 100 μg
Application Codes Clone: ELISA; neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: hVHH
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original VHH format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds human interleukin-13. It is also reported to cross react with cynomolgus monkey and rhesus monkey IL13. Interleukin-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. It inhibits the production of inflammatory cytokines (IL-1, IL-6, TNF, IL-8) by LPS-stimulated monocytes. It synergizes with IL2 in regulating interferon-gamma synthesis. It is a mediator of allergic inflammation and different diseases including asthma.
Application Notes: The binding characterization of this antibody to human, cynomolgus monkey and rhesus monkey IL-13 was done using ELISA. The binding affinity of the original single chain VHH antibody was assessed using BIAcore analysis. It was reported that the original VHH antibody bound human and cynomolgus monkey IL13 with a binding affinity of 130 pM and 3.2 pM respectively. This antibody shows neutralizing potency for human, cynomolgus monkey and rhesus IL-13 (US20110236380).

Product Class:	Purified
Clone ID:	DOM10-53-616
Synonyms:	IL13; NC30; Interleukin-13; DOM10-53-546; DOM10-53-386
Amount:	100 μg
Application Codes Clone:	ELISA; neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	hVHH
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric mouse antibody was made using the variable domain sequences of the original VHH format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds human interleukin-13. It is also reported to cross react with cynomolgus monkey and rhesus monkey IL13. Interleukin-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. It inhibits the production of inflammatory cytokines (IL-1, IL-6, TNF, IL-8) by LPS-stimulated monocytes. It synergizes with IL2 in regulating interferon-gamma synthesis. It is a mediator of allergic inflammation and different diseases including asthma.
Application Notes:	The binding characterization of this antibody to human, cynomolgus monkey and rhesus monkey IL-13 was done using ELISA. The binding affinity of the original single chain VHH antibody was assessed using BIAcore analysis. It was reported that the original VHH antibody bound human and cynomolgus monkey IL13 with a binding affinity of 130 pM and 3.2 pM respectively. This antibody shows neutralizing potency for human, cynomolgus monkey and rhesus IL-13 (US20110236380).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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