Mfg Part Number
Ab03209-34.11
Vector Labs Ab03209-34.11 Anti-IL-13 [DOM10-53-616], Camelid VHH, His-tagged, (100 μg)
Quick Overview
The original antibody DOM10-53-546 was isolated from in-line fusion libraries selected against human IL-13. This antibody (DOM10-53-616) was generated by replacing the CDR2 of DOM10-53-546 with that of DOM10-53-386.
$692.90
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | DOM10-53-616 |
| Heavy Chain Modification: | His-tagged |
| Synonyms: | IL13; NC30; Interleukin-13; DOM10-53-546; DOM10-53-386 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; neutralize |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | hVHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds human interleukin-13. It is also reported to cross react with cynomolgus monkey and rhesus monkey IL13. Interleukin-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. It inhibits the production of inflammatory cytokines (IL-1, IL-6, TNF, IL-8) by LPS-stimulated monocytes. It synergizes with IL2 in regulating interferon-gamma synthesis. It is a mediator of allergic inflammation and different diseases including asthma. |
| Application Notes: | The binding characterization of this antibody to human, cynomolgus monkey and rhesus monkey IL-13 was done using ELISA. The binding affinity of the original single chain VHH antibody was assessed using BIAcore analysis. It was reported that the original VHH antibody bound human and cynomolgus monkey IL13 with a binding affinity of 130 pM and 3.2 pM respectively. This antibody shows neutralizing potency for human, cynomolgus monkey and rhesus IL-13 (US20110236380). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |