Vector Labs Ab03211-1.1 Anti-IL-13 [CNTO607], Mouse IgG1, lambda (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: CNTO607
Synonyms: IL13; NC30; Interleukin-13; MOR3406
Amount: 100 μg
Application Codes Clone: ELISA; neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds an epitope at the surface formed by helices A and D of human interleukin-13. This epitope overlaps with the IL-4Ralpha/IL-13Ralpha1 receptor-binding site, which explains the neutralizing effect of CNTO607. IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. It inhibits the production of inflammatory cytokines (IL-1, IL-6, TNF, IL-8) by LPS-stimulated monocytes. It synergizes with IL2 in regulating interferon-gamma synthesis. It is a mediator of allergic inflammation and different diseases including asthma.
Application Notes: The original IgG1 version of this antibody binds human IL-13 with an affinity of 18pM and prevents binding of IL-13 to both IL-13Rα1 and IL-4Rα. This antibody can bind native wild type and recombinant human IL-13 in an ELISA (PMID: 19361524). This antibody is capable of neutralizing IL13 activity in the TF-1 and in the IL-13Rα1 receptor binding assay (US20080044420). This antibody has the tendency to self associate. The IgG1 version of this antibody can be concentrated to ∼13 mg/ml before irreversible precipitation occurs (PMID: 22915597). The relative binding affinity of the IgG1 version of this antibody was determined to be 18.4 pM (PMID: 22915597).

Product Class:	Purified
Clone ID:	CNTO607
Synonyms:	IL13; NC30; Interleukin-13; MOR3406
Amount:	100 μg
Application Codes Clone:	ELISA; neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds an epitope at the surface formed by helices A and D of human interleukin-13. This epitope overlaps with the IL-4Ralpha/IL-13Ralpha1 receptor-binding site, which explains the neutralizing effect of CNTO607. IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. It inhibits the production of inflammatory cytokines (IL-1, IL-6, TNF, IL-8) by LPS-stimulated monocytes. It synergizes with IL2 in regulating interferon-gamma synthesis. It is a mediator of allergic inflammation and different diseases including asthma.
Application Notes:	The original IgG1 version of this antibody binds human IL-13 with an affinity of 18pM and prevents binding of IL-13 to both IL-13Rα1 and IL-4Rα. This antibody can bind native wild type and recombinant human IL-13 in an ELISA (PMID: 19361524). This antibody is capable of neutralizing IL13 activity in the TF-1 and in the IL-13Rα1 receptor binding assay (US20080044420). This antibody has the tendency to self associate. The IgG1 version of this antibody can be concentrated to ∼13 mg/ml before irreversible precipitation occurs (PMID: 22915597). The relative binding affinity of the IgG1 version of this antibody was determined to be 18.4 pM (PMID: 22915597).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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