JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Skip to the beginning of the images gallery

Mfg Part Number

Ab03216-10.29-BS

Vector Labs Ab03216-10.29-BS Anti-IL-8 [6G4.2.5V11N35A], Human Fab fragment, His-Tagged, kappa (1 mg)

VECTOR LABS

Be the first to review this product

Quick Overview

The original mouse antibody 6G4.2.5 was generated by immunizing BALB/c mice with recombinant human IL-8. The humanized version is 6G4.2.5 V11N35A was generated by grafting CDRs of mouse parental antibody onto human framework regions.

$5,162.30

Order will ship within 1-3 business days

Description

Product Class: Purified
Clone ID: 6G4.2.5V11N35A
Heavy Chain Modification: His-Tagged
Synonyms: IL8; Interleukin-8; CXCL8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor; 6G4.2.5; V11N35A; 6G4V11N35A
Amount: 1 mg
Application Codes Clone: ELISA; neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS only.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds human IL-8, which is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. This antibody cross reacts with rabbit and rhesus monkey IL-8.
Application Notes: This antibody is capable of neutralizing the biological activity of wild-type human IL-8. This antibody is reported to inhibit human wild type IL-8, human monomeric IL-8, rabbit IL-8, and rhesus IL-8 mediated neutrophil chemotaxis (US6025158). The binding characterization of this antibody was done using ELISA. The Fab version of this antibody binds human IL-8 with an affinity of 114 pM (US6025158).

Product Class:	Purified
Clone ID:	6G4.2.5V11N35A
Heavy Chain Modification:	His-Tagged
Synonyms:	IL8; Interleukin-8; CXCL8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor; 6G4.2.5; V11N35A; 6G4V11N35A
Amount:	1 mg
Application Codes Clone:	ELISA; neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS only.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds human IL-8, which is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. This antibody cross reacts with rabbit and rhesus monkey IL-8.
Application Notes:	This antibody is capable of neutralizing the biological activity of wild-type human IL-8. This antibody is reported to inhibit human wild type IL-8, human monomeric IL-8, rabbit IL-8, and rhesus IL-8 mediated neutrophil chemotaxis (US6025158). The binding characterization of this antibody was done using ELISA. The Fab version of this antibody binds human IL-8 with an affinity of 114 pM (US6025158).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

Reviews