Mfg Part Number
Ab03217-1.1
Vector Labs Ab03217-1.1 Anti-IL-8 [M36-11], Mouse IgG1, lambda (100 μg)
Quick Overview
The original antibody 4-123-36 was isolated from a human single domain antibody (scFv) library by screening the library against extracellular portions of the human IL-8. Affinity maturation of this clone using mutagenesis by error-prone PCR resulted in the generation of M36-11.
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| Product Class: | Purified |
|---|---|
| Clone ID: | M36-11 |
| Synonyms: | IL8; Interleukin-8; CXCL8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor; 4-123-36 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; block |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human interleukin-8. Interleukin-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. |
| Application Notes: | The binding of this affinity-maturated antibody to hIL8 was analyzed using ELISA. This antibody is capable of blocking the biological activity of human interleukin 8 at a concentration of 1 and 10 μg/mL in a neutrophil chemotaxis assay (PMID: 20718039). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |