Mfg Part Number
Ab03235-1.159-BS
Vector Labs Ab03235-1.159-BS Anti-CTLA-4 [NB25B-17], Mouse IgG1-Fc Fusion, (1 mg)
Quick Overview
The original antibody was generated by immunizing alpaca with human CTLA-4, followed by antibody library construction and phage display-based selection.
$5,162.30
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| Product Class: | Purified |
|---|---|
| Clone ID: | NB25B-17 |
| Synonyms: | Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CD152 |
| Amount: | 1 mg |
| Application Codes Clone: | FACS; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS only. |
| Original Format: | VHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | The antibody is specific for CTLA-4. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. |
| Application Notes: | The binding affinity of humanized VHH-Fc chimeric antibody to human CTLA-4 expressed in CHO cells was shown by FACS experiments. The blocking activity of the humanized VHH-Fc chimeric antibody to the binding of CTLA-4 to CD80 or CD86 was shown using FACS. The antitumor activity of the humanized antibody was demonstrated in vivo in animal models. Specifically, a tumor animal model was established by inoculating mice with human breast cancer cells MDA-MB-231 (ATCC) to induce breast cancer. Mice were grouped and administered with the humanized version of the antibody, and tumor volume in tumor-bearing animals was measured periodically in size. Results showed that the humanized version of the antibody was able to significantly reduce tumor volume in tumor-bearing mice (CN113121689). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |