Mfg Part Number
Ab03237-10.3
Vector Labs Ab03237-10.3 Anti-FcRn [h22-0015], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing Balb/c mice with recombinant FcRn.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | h22-0015 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | IgG receptor FcRn large subunit p51; FCGRT; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor |
| Amount: | 200 μg |
| Application Codes Clone: | Blocking; in vitro; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | The antibody is specific for human FcRn. The neonatal Fc receptor is a cell surface receptor that transfers passive humoral immunity from the mother to the newborn. |
| Application Notes: | The antibody was employed in blocking experiments with HEK293 cells that overexpress FcRn. The results showed that the antibody has a good effect of blocking the binding of IgG to FcRn at the cellular level (IC50: 11.4nM). The effect of the antibody was tested in human FcRn transgenic mice. The antibody was able to increase IgG catabolism in vivo by blocking FcRn binding (CN113484526). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |