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Mfg Part Number

Ab03274-1.1

Vector Labs Ab03274-1.1 Anti-Apical membrane antigen 1 [F8.12.19], Mouse IgG1, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with recombinant ectoplasmic region of AMA1 from Plasmodium vivax.

$517.40

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Description

Product Class: Purified
Clone ID: F8.12.19
Synonyms: AMA1;AMA-1; Apical merozoite antigen 1;
Amount: 200 μg
Application Codes Clone: ELISA; IF; SPR; WB
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody recognizes a discontinuous conformational epitope located on domain III of the ectoplasmic region of the apical membrane antigen 1 (AMA1) of Plasmodium vivax and also cross reacts with AMA1 from Plasmodium knowlesi, Plasmodium cynomolgi, Plasmodium berghei and Plasmodium falciparum. AMA1 is involved in parasite invasion of erythrocytes.
Application Notes: This antibody can recognize AMA1 of Plasmodium vivax, Plasmodium knowlesi, Plasmodium cynomolgi, Plasmodium berghei and Plasmodium falciparum in an immunofluorescence assay on mature schizonts. The binding region is a discontinuous epitope located on domain III of the ectoplasmic region, the major component being a loop containing a cystine knot. The binding of F8.12.19 to recombinant AMA1 from both P. vivax and P. falciparum was measured by surface plasmon resonance. This antibody shows no function-blocking effect was detected in ex vivo parasite growth inhibition assays. (PMID: 17229439). This antibody a dilution of 1:16,000 was used for the detection of recombinant PvAMA-1 and recombinant PvAMA-DII-III using dot-blot and ELISA assays (PMID: 28855657). This antibody was also used for the identification of PfAMA1 using western blot (PMID: 25236489).

Product Class:	Purified
Clone ID:	F8.12.19
Synonyms:	AMA1;AMA-1; Apical merozoite antigen 1;
Amount:	200 μg
Application Codes Clone:	ELISA; IF; SPR; WB
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody recognizes a discontinuous conformational epitope located on domain III of the ectoplasmic region of the apical membrane antigen 1 (AMA1) of Plasmodium vivax and also cross reacts with AMA1 from Plasmodium knowlesi, Plasmodium cynomolgi, Plasmodium berghei and Plasmodium falciparum. AMA1 is involved in parasite invasion of erythrocytes.
Application Notes:	This antibody can recognize AMA1 of Plasmodium vivax, Plasmodium knowlesi, Plasmodium cynomolgi, Plasmodium berghei and Plasmodium falciparum in an immunofluorescence assay on mature schizonts. The binding region is a discontinuous epitope located on domain III of the ectoplasmic region, the major component being a loop containing a cystine knot. The binding of F8.12.19 to recombinant AMA1 from both P. vivax and P. falciparum was measured by surface plasmon resonance. This antibody shows no function-blocking effect was detected in ex vivo parasite growth inhibition assays. (PMID: 17229439). This antibody a dilution of 1:16,000 was used for the detection of recombinant PvAMA-1 and recombinant PvAMA-DII-III using dot-blot and ELISA assays (PMID: 28855657). This antibody was also used for the identification of PfAMA1 using western blot (PMID: 25236489).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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