Mfg Part Number
Ab03280-23.159
Vector Labs Ab03280-23.159 Anti-Laminin-211 LG5 [PL60B3], Rabbit IgG-Fc Fusion, (200 μg)
Quick Overview
The original antibody was generated by immunizing an alpaca with a mixture of transfected CHO cells expressing human and mouse laminin 211 LG5 domain.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | PL60B3 |
| Synonyms: | Merosin; Laminin subunit alpha-2; LAMA2; Laminin 211; laminin G-like 5 domain; LG5; g-like 4 and 5 domain; LG-4/5; Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | VHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody recognizes human and mouse laminin 211 LG5 domain. Laminin is a large extracellular heterotrimeric glycoprotein and a major constituent of the basement membrane. It is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-211 (formerly named merosin) is the most abundant laminin isoform in the basement membrane of adult skeletal muscle. Laminin-211 deficiency leads to the most common form of congenital muscular dystrophy in childhood, MDC1A. |
| Application Notes: | The binding specificity of this antibody to human and mouse laminin 211 LG5 expressed on the surface of CHO cells was confirmed using ELISA and flow cytometry. The binding affinity of the original VHH antibody to human beta dystroglycan was determined to be 68 pM. This antibody was used in combination with anti-beta dystroglycan antibody P38G1 for the generation of a bispecific antibody (CN113651891). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |