Mfg Part Number
Ab03308-10.0
Vector Labs Ab03308-10.0 Anti-DOG1 [19F2], Human IgG1, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing mice with recombinant protein DOG1.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 19F2 |
| Synonyms: | Discovered On Gastrointestinal Stromal Tumors Protein 1; SP31; Anoctamin-1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2; CGMCC NO. 20771 |
| Amount: | 200 μg |
| Application Codes Clone: | IHC; WB; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2b |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | The antibody is specific for DOG1. DOG1 is a calcium-activated chloride channel (CaCC) which plays a role in the transepithelial anion transport and smooth muscle contraction. It is required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles and it acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. |
| Application Notes: | The antibody 19F2 and the commercial antibody SP31 were used to stain breast tissue and gastrointestinal tumor in immunohistochemistry. Results showed the antibody specificity is equivalent to the commercial antibody. Further, the staining intensity of the antibody 19F2 was higher than the commercial antibody (CN113045652A). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |