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Mfg Part Number

Ab03365-23.0

Vector Labs Ab03365-23.0 Anti-CD134 [9D1], Rabbit IgG, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing 6-8 weeks old female BALB/c mice with human OX40 protein.

$517.40

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Description

Product Class: Purified
Clone ID: 9D1
Synonyms: OX40; OX-40; OX40L receptor; TNFRSF4; TXGP1L; Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; TAX transcriptionally-activated glycoprotein 1 receptor; 08-9D1; 9D1-mHvKv
Amount: 200 μg
Application Codes Clone: ELISA; FC; therapeutic
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds human CD134 (OX40; TNFRFS4). This molecule acts as a receptor for TNFSF4/OX40L/GP34. It is a costimulatory molecule implicated in long-term T-cell immunity.
Application Notes: The binding characterization of this antibody to human OX40 was done using ELISA. The binding reactivity of this antibody to human, mouse and rhesus monkey OX40 expressed on CHO cells was determined using flow cytometry. This antibody was shown to cross react with human and rhesus monkey OX40 and not mouse OX40. The binding affinity of the original mouse IgG1 antibody for human OX40 was determined using surface plasmon resonance and was found to be Kd= 0.389 nM. The anti-tumor activity of this antibody was studied in an in vivo mouse colon cancer model. MC-38 cancer tumor cells (colon adenocarcinoma cells) were injected subcutaneously into B-hOX40 humanized mice and the mice were then treated with this antibody. This antibody was shown to have good percent tumor growth inhibition (CN111763258).

Product Class:	Purified
Clone ID:	9D1
Synonyms:	OX40; OX-40; OX40L receptor; TNFRSF4; TXGP1L; Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; TAX transcriptionally-activated glycoprotein 1 receptor; 08-9D1; 9D1-mHvKv
Amount:	200 μg
Application Codes Clone:	ELISA; FC; therapeutic
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds human CD134 (OX40; TNFRFS4). This molecule acts as a receptor for TNFSF4/OX40L/GP34. It is a costimulatory molecule implicated in long-term T-cell immunity.
Application Notes:	The binding characterization of this antibody to human OX40 was done using ELISA. The binding reactivity of this antibody to human, mouse and rhesus monkey OX40 expressed on CHO cells was determined using flow cytometry. This antibody was shown to cross react with human and rhesus monkey OX40 and not mouse OX40. The binding affinity of the original mouse IgG1 antibody for human OX40 was determined using surface plasmon resonance and was found to be Kd= 0.389 nM. The anti-tumor activity of this antibody was studied in an in vivo mouse colon cancer model. MC-38 cancer tumor cells (colon adenocarcinoma cells) were injected subcutaneously into B-hOX40 humanized mice and the mice were then treated with this antibody. This antibody was shown to have good percent tumor growth inhibition (CN111763258).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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