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Mfg Part Number

Ab03371-10.0

Vector Labs Ab03371-10.0 Anti-HLA-A2 [MBW1], Human IgG1, lambda (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated from the peripheral blood lymphocytes obtained from a multiparous volunteer 1 week postpartum were transformed in vitro by Epstein-Barr virus and electro fused with the heterohybridoma fusion partner, K6H6/B5. The screening for specific clone was done using micro lymphocytotoxicity assay.

$517.40

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Description

Product Class: Purified
Clone ID: MBW1
Synonyms: HLA-A; Human leukocyte antigen A; HLA class I histocompatibility antigen; A-2 alpha chain; MHC class I antigen A-2 HLA-A; HLA class I histocompatibility antigen A-28 alpha chain; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A-28
Amount: 200 μg
Application Codes Clone: ELISA; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgM
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human IgM format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: The antibody specifically binds human HLA-A2 and does not cross react with A28, Aw68, or Aw69 antigens.
Application Notes: This antibody specifically reacts with human HLA-A2 and does not cross react with A28, Aw68, or Aw69 antigens (PMID: 2160447). The reactivity of this antibody to human HLA-A2 was determined using ELISA. The reactivity of this antibody towards HLA-A2 was abolished by substitutions in the a1 domain, specifically the substitutions of alanine for glutamic acid at position 58 (E58A) and either a valine or arginine substitution for glycine at position 62 (G62V or G62R). The reactivity of this antibody to surface bound HLA-A*0201 was determined using complement-dependent cytotoxicity (CDC) assay (PMID: 9862700).

Product Class:	Purified
Clone ID:	MBW1
Synonyms:	HLA-A; Human leukocyte antigen A; HLA class I histocompatibility antigen; A-2 alpha chain; MHC class I antigen A-2 HLA-A; HLA class I histocompatibility antigen A-28 alpha chain; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A-28
Amount:	200 μg
Application Codes Clone:	ELISA; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgM
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted human antibody was made using the variable domain sequences of the original Human IgM format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	The antibody specifically binds human HLA-A2 and does not cross react with A28, Aw68, or Aw69 antigens.
Application Notes:	This antibody specifically reacts with human HLA-A2 and does not cross react with A28, Aw68, or Aw69 antigens (PMID: 2160447). The reactivity of this antibody to human HLA-A2 was determined using ELISA. The reactivity of this antibody towards HLA-A2 was abolished by substitutions in the a1 domain, specifically the substitutions of alanine for glutamic acid at position 58 (E58A) and either a valine or arginine substitution for glycine at position 62 (G62V or G62R). The reactivity of this antibody to surface bound HLA-A*0201 was determined using complement-dependent cytotoxicity (CDC) assay (PMID: 9862700).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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