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Mfg Part Number

Ab03377-8.4

Vector Labs Ab03377-8.4 Anti-CD226 [FMU-mCD226.1], Rat IgG2b, Fc Silent™, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing CD226KO (CD226 knockout) mice with purified CD226-Fc recombinant fusion protein.

$517.40

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Description

Product Class: Purified
Clone ID: FMU-mCD226.1
Heavy Chain Modification: Fc Silent™
Synonyms: DNAM1; DNAM-1; TLisA1; PTA-1; CD226 antigen; DNAX accessory molecule 1; T lineage specific activation antigen 1; platelet and T cell antigen 1
Amount: 200 μg
Application Codes Clone: ELISA; FC; WB
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds mouse CD226. This protein is expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. It acts as cell surface receptor for NECTIN2. On binding with ligand it stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG.
Application Notes: The binding of this antibody to recombinant mouse CD226-Fc fusion protein was determined using indirect ELISA. This antibody is capable of binding mouse CD226 expressed on wild-type mouse platelets in a flow cytometric assay. This antibody was also reported to promote platelet aggregation. This antibody can be used to identify CD226 expressed in platelet lysates using western blot (CN111363042).

Product Class:	Purified
Clone ID:	FMU-mCD226.1
Heavy Chain Modification:	Fc Silent™
Synonyms:	DNAM1; DNAM-1; TLisA1; PTA-1; CD226 antigen; DNAX accessory molecule 1; T lineage specific activation antigen 1; platelet and T cell antigen 1
Amount:	200 μg
Application Codes Clone:	ELISA; FC; WB
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds mouse CD226. This protein is expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. It acts as cell surface receptor for NECTIN2. On binding with ligand it stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG.
Application Notes:	The binding of this antibody to recombinant mouse CD226-Fc fusion protein was determined using indirect ELISA. This antibody is capable of binding mouse CD226 expressed on wild-type mouse platelets in a flow cytometric assay. This antibody was also reported to promote platelet aggregation. This antibody can be used to identify CD226 expressed in platelet lysates using western blot (CN111363042).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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