Mfg Part Number
Ab03381-10.3
Vector Labs Ab03381-10.3 Anti-NKp46 [NKP46-4], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was isolated using phage display technology after three rounds of panning against human NKp-46.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | NKP46-4 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; hNKp46; CD335 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | The antibody is specific for human NKp46. The antibody cross-reacts with cynomolgus monkey and rhesus macaque NK46 but does not cross-react with mouse NKp46. NKp46 is a receptor expressed by NK cells. |
| Application Notes: | The binding specificity of this antibody towards human, cynomolgus monkey and rhesus monkey NKp-46 was determined using ELISA and flow cytometry. The binding of this antibody to NKp-46 expressed on the surface of CHOK1 and NK cells was confirmed using flow cytometry. The original IgG antibody bound ectodomain of human NKp-46 with a binding affinity of Kd= 1.1 nM. This binding of this antibody to NK cells resulted in an increase in the interferon gamma release (CN113637074). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |