Vector Labs Ab03388-1.1 Anti-MOG [8.18-C5], Mouse IgG1, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 8.18-C5
Synonyms: Myelin-oligodendrocyte glycoprotein; 8.18C5; 8-18C5
Amount: 200 μg
Application Codes Clone: IHC; WB; IF; ELISA; FC; Crystallization; in vivo
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: The antibody binds specifically to MOG, recognising a conformational epitope. MOG is a transmembrane glycoprotein expressed on the surface of oligodendrocytes in the central nervous system, that plays an important role in maintaining the structure of the myelin sheath. Monoclonal antibodies that target MOG are involved in the pathogenesis of the demyelinating disorder multiple sclerosis (MS). Animals injected with anti-MOG antibodies have been shown to display symptoms of human MS, and can thereby be used as models to study the development of the disease. The epitope interacting with the antibody is expressed in rat, mouse, guinea pig, cow, monkey, and humans.
Application Notes: This antibody was detected in white matter tracts of the central nervous system by immununohistochemistry. The antibody detected MOG by western blot analysis (Linnington et al., 1984; PMID: 6207204). The specificity of the original format of the antibody and Fab fragment was confirmed by ELISA analysis (Litzenburger et al., 1998; PMID: 9653093 and Menge et al., 2011; PMID: 22093619). This antibody was used for detection of MOG expressed on B cells by flow cytometry (Na et al., 2021; PMID: 34149706). MOG from HeLa cells were immunoprecipitated with the antibody. Immunofluorescence was performed on HeLa cells using this antibody (Boyle et al., 2007; PMID: 17573820). The antibody triggered in vivo expansion of CD4⁺ T cells in spleen, inguinal, and cervical lymph nodes (Kinzel et al. 2016; PMID: 27022743). The crystal structure of the Fab version of this antibody was determined in complex with MOG^Igd (Breithaupt et al., 2003; PMID: 12874380).

Product Class:	Purified
Clone ID:	8.18-C5
Synonyms:	Myelin-oligodendrocyte glycoprotein; 8.18C5; 8-18C5
Amount:	200 μg
Application Codes Clone:	IHC; WB; IF; ELISA; FC; Crystallization; in vivo
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	The antibody binds specifically to MOG, recognising a conformational epitope. MOG is a transmembrane glycoprotein expressed on the surface of oligodendrocytes in the central nervous system, that plays an important role in maintaining the structure of the myelin sheath. Monoclonal antibodies that target MOG are involved in the pathogenesis of the demyelinating disorder multiple sclerosis (MS). Animals injected with anti-MOG antibodies have been shown to display symptoms of human MS, and can thereby be used as models to study the development of the disease. The epitope interacting with the antibody is expressed in rat, mouse, guinea pig, cow, monkey, and humans.
Application Notes:	This antibody was detected in white matter tracts of the central nervous system by immununohistochemistry. The antibody detected MOG by western blot analysis (Linnington et al., 1984; PMID: 6207204). The specificity of the original format of the antibody and Fab fragment was confirmed by ELISA analysis (Litzenburger et al., 1998; PMID: 9653093 and Menge et al., 2011; PMID: 22093619). This antibody was used for detection of MOG expressed on B cells by flow cytometry (Na et al., 2021; PMID: 34149706). MOG from HeLa cells were immunoprecipitated with the antibody. Immunofluorescence was performed on HeLa cells using this antibody (Boyle et al., 2007; PMID: 17573820). The antibody triggered in vivo expansion of CD4⁺ T cells in spleen, inguinal, and cervical lymph nodes (Kinzel et al. 2016; PMID: 27022743). The crystal structure of the Fab version of this antibody was determined in complex with MOG^Igd (Breithaupt et al., 2003; PMID: 12874380).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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