Mfg Part Number
Ab03418-3.0
Vector Labs Ab03418-3.0 Anti-CCR2 [4.9], Mouse IgG2b, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing human immunoglobulin generating XENOMOUSE™ mice with human CCR2 antigen.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 4.9 |
| Synonyms: | CD192; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CMKBR2; 4.9.2 |
| Amount: | 200 μg |
| Application Codes Clone: | FC; ELISA; antagonist |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody specifically binds an epitope located within the 2nd extracellular loop of human CCR2. The human C-C chemokine receptor type 2 is a key functional receptor for CCL2 but can also bind CCL7 and CCL12. |
| Application Notes: | The binding specificity of this antibody to full length CCR2, and 1St and 2nd loop of CCR2 was determined using ELISA. The binding reactivity of this antibody to the surface bound CCR2 receptors was confirmed with flow cytometry. This antibody can positively inhibit chemotaxis of THP-1 monocytes. The therapeutic effects of this antibody were studied in in vivo mouse models of inflammation, multiple sclerosis and neuropathic pain (US8710191). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |