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Mfg Part Number

Ab03420-23.0

Vector Labs Ab03420-23.0 Anti-CD40 [3B2], Rabbit IgG, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing mice with recombinant human CD40 protein.

$517.40

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Description

Product Class: Purified
Clone ID: 3B2
Synonyms: TNFRS5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor CDw40; CD154R; 19-3B2
Amount: 200 μg
Application Codes Clone: FC; therapeutic
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody recognizes and binds human and primate CD40, but does not cross react with mouse CD40. CD40 acts as a receptor for TNFSF5/CD40LG. This protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
Application Notes: The reactivity of this antibody to human, Ganlamp monkey and mouse CD40 protein expressed on the surface of CHO cells was determined using flow cytometry. This antibody positively binds human and primate CD40 proteins and does not cross react with mouse CD40. The original mouse IgG antibody binds human CD40 with a binding affinity of kd= 6.13X10^(-10) M. The tumor inhibitory activity of this antibody was also tested in vivo in B-HCD40 mice injected with murine MC-38 cells (colon cancer cells). This antibody exhibited good tumor inhibitory effect (CN111763259).

Product Class:	Purified
Clone ID:	3B2
Synonyms:	TNFRS5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor CDw40; CD154R; 19-3B2
Amount:	200 μg
Application Codes Clone:	FC; therapeutic
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody recognizes and binds human and primate CD40, but does not cross react with mouse CD40. CD40 acts as a receptor for TNFSF5/CD40LG. This protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
Application Notes:	The reactivity of this antibody to human, Ganlamp monkey and mouse CD40 protein expressed on the surface of CHO cells was determined using flow cytometry. This antibody positively binds human and primate CD40 proteins and does not cross react with mouse CD40. The original mouse IgG antibody binds human CD40 with a binding affinity of kd= 6.13X10^(-10) M. The tumor inhibitory activity of this antibody was also tested in vivo in B-HCD40 mice injected with murine MC-38 cells (colon cancer cells). This antibody exhibited good tumor inhibitory effect (CN111763259).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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