Vector Labs Ab03429-10.3 Anti-Lox-1 [AbAb01LOX1], Human IgG1, Fc Silent™, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: AbAb01LOX1
Heavy Chain Modification: Fc Silent™
Synonyms: LOX1; hLOX-1; OLR1; CLEC8A; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; Oxidized low-density lipoprotein receptor 1 soluble form
Amount: 200 μg
Application Codes Clone: ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds oxidized low density lipoprotein (ox-LDL), which is a receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis.
Application Notes: This antibody can be used for the detection of Lox-1, which is a marker for early diagnosis of atherosclerosis. The binding characterization of this antibody was done using ELISA. The binding affinity of this antibody for human Lox-1 was determined using Bio-layer Interferometry (BLI) and it was reported that the binding affinity of this scFv antibody was Kd= 6.69 nM (CN107216390).

Product Class:	Purified
Clone ID:	AbAb01LOX1
Heavy Chain Modification:	Fc Silent™
Synonyms:	LOX1; hLOX-1; OLR1; CLEC8A; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; Oxidized low-density lipoprotein receptor 1 soluble form
Amount:	200 μg
Application Codes Clone:	ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds oxidized low density lipoprotein (ox-LDL), which is a receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis.
Application Notes:	This antibody can be used for the detection of Lox-1, which is a marker for early diagnosis of atherosclerosis. The binding characterization of this antibody was done using ELISA. The binding affinity of this antibody for human Lox-1 was determined using Bio-layer Interferometry (BLI) and it was reported that the binding affinity of this scFv antibody was Kd= 6.69 nM (CN107216390).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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