Vector Labs Ab03435-10.3 Anti-CD39 [I-392], Human IgG1, Fc Silent™, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: I-392
Heavy Chain Modification: Fc Silent™
Synonyms: ENTPD1; NTPDase 1; Ectonucleoside triphosphate Di phosphohydrolase 1; Ecto-ATP Di phosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen
Amount: 200 μg
Application Codes Clone: FC; ELISA; neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody recognizes and binds human CD39. NTPDase 1 (ectonucleoside triphosphate diphosphohydrolase, also known as CD39/ENTPD1 or vascular CD39, functions together with another enzyme, CD73 (ecto-5'- nucleosidase), to hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. This protein could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.
Application Notes: The binding characterization of this antibody for CD39 expressed on Ramos cells was done using flow cytometry (WO2018065552). The binding of this antibody to various recombinant human CD39 isoforms was detected using ELISA. This antibody bound only vascular CD39, without any binding to CD39-L1, CD39-L2, CD39-L3 or CD39-L4. This antibody did not induce or increase CD39 down regulation. It was reported that this antibody is very potent at blocking CD39 enzymatic activity and is capable of neutralizing ATPase activity (US20190153113).

Product Class:	Purified
Clone ID:	I-392
Heavy Chain Modification:	Fc Silent™
Synonyms:	ENTPD1; NTPDase 1; Ectonucleoside triphosphate Di phosphohydrolase 1; Ecto-ATP Di phosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen
Amount:	200 μg
Application Codes Clone:	FC; ELISA; neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody recognizes and binds human CD39. NTPDase 1 (ectonucleoside triphosphate diphosphohydrolase, also known as CD39/ENTPD1 or vascular CD39, functions together with another enzyme, CD73 (ecto-5'- nucleosidase), to hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. This protein could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.
Application Notes:	The binding characterization of this antibody for CD39 expressed on Ramos cells was done using flow cytometry (WO2018065552). The binding of this antibody to various recombinant human CD39 isoforms was detected using ELISA. This antibody bound only vascular CD39, without any binding to CD39-L1, CD39-L2, CD39-L3 or CD39-L4. This antibody did not induce or increase CD39 down regulation. It was reported that this antibody is very potent at blocking CD39 enzymatic activity and is capable of neutralizing ATPase activity (US20190153113).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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