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Mfg Part Number

Ab03458-10.3

Vector Labs Ab03458-10.3 Anti-LMP1 [H11F6], Human IgG1, Fc Silent™, lambda (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was isolated from a human non-immune scFv phage display library by screening antibodies against a 44-mer polypeptide corresponding to the CTAR1/TES1 site of LMP1 (TES1 polypeptide).

$570.70

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Description

Product Class: Purified
Clone ID: H11F6
Heavy Chain Modification: Fc Silent™
Synonyms: BNLF1; LMP-1; Latent membrane protein 1; Protein p63
Amount: 100 μg
Application Codes Clone: ELISA
Shipping Temperature: Wet Ice
Origin Pub PMID: 14659750
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody specifically binds the CTAR1/TES1 (C terminus activation region 1/transformation effector site 1) which comprises the membrane-most proximal 34 amino acids (amino acid residues 196–231) of carboxy-terminal cytoplasmic tail of the oncogenic latent membrane protein 1 of the Epstein-Barr virus (EBV). EBV latent membrane protein 1 (LMP1) is essential to virus-induced B cell immortalization and the downregulation of cell adhesion molecules that increases cell motility. It acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation.
Application Notes: The binding characterization of this antibody to the TES1 polypeptide of the LMP1 protein of Epstein-Barr virus was done using ELISA. This antibody can selectively block F-LMP1-induced NFkappaB activity that was mediated through the TES1-site and to bind LMP1 protein with high efficiency (PMID: 14659750).

Product Class:	Purified
Clone ID:	H11F6
Heavy Chain Modification:	Fc Silent™
Synonyms:	BNLF1; LMP-1; Latent membrane protein 1; Protein p63
Amount:	100 μg
Application Codes Clone:	ELISA
Shipping Temperature:	Wet Ice
Origin Pub PMID:	14659750
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody specifically binds the CTAR1/TES1 (C terminus activation region 1/transformation effector site 1) which comprises the membrane-most proximal 34 amino acids (amino acid residues 196–231) of carboxy-terminal cytoplasmic tail of the oncogenic latent membrane protein 1 of the Epstein-Barr virus (EBV). EBV latent membrane protein 1 (LMP1) is essential to virus-induced B cell immortalization and the downregulation of cell adhesion molecules that increases cell motility. It acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation.
Application Notes:	The binding characterization of this antibody to the TES1 polypeptide of the LMP1 protein of Epstein-Barr virus was done using ELISA. This antibody can selectively block F-LMP1-induced NFkappaB activity that was mediated through the TES1-site and to bind LMP1 protein with high efficiency (PMID: 14659750).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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