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Mfg Part Number

Ab03460-10.0

Vector Labs Ab03460-10.0 Anti-Tissue factor [hTFFab148H], Human IgG1, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was isolated from a human Fab antibody library generated from peripheral blood collected from 300 healthy individuals.

$570.70

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Description

Product Class: Purified
Clone ID: hTFFab148H
Synonyms: CD142; TF; hTF; F3; Coagulation factor III; Thromboplastin; platelet tissue factor; factor III
Amount: 100 μg
Application Codes Clone: ELISA; WB; Neutralize
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: Fab
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds human tissue factor (TF) a hemostatic protein which is involved in the extrinsic pathway of coagulation. TF is receptor for circulating serine protease factor VIIa, activating the catalytic VIIa protease domain. The complex formed functions to activate the zymogen factor X into activated factor Xa, which then catalyzes the formation of Prothrombin to Thrombin. The pathways results in a fibrin clot which acts to stop bleeding. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Application Notes: The binding characterization of this Fab antibody was done using ELISA and dot blot. This antibody shows positive plasma coagulation inhibitory activity. This antibody is capable of neutralizing human tissue factor in vitro by inhibiting the binding of TF factor/Vlla complex to factor X. The inhibition rate increase with the concentration. The pharmacodynamic and pharmacokinetic activity of this antibody was studied in vivo in rat models (CN101423552).

Product Class:	Purified
Clone ID:	hTFFab148H
Synonyms:	CD142; TF; hTF; F3; Coagulation factor III; Thromboplastin; platelet tissue factor; factor III
Amount:	100 μg
Application Codes Clone:	ELISA; WB; Neutralize
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	Fab
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted human antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds human tissue factor (TF) a hemostatic protein which is involved in the extrinsic pathway of coagulation. TF is receptor for circulating serine protease factor VIIa, activating the catalytic VIIa protease domain. The complex formed functions to activate the zymogen factor X into activated factor Xa, which then catalyzes the formation of Prothrombin to Thrombin. The pathways results in a fibrin clot which acts to stop bleeding. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Application Notes:	The binding characterization of this Fab antibody was done using ELISA and dot blot. This antibody shows positive plasma coagulation inhibitory activity. This antibody is capable of neutralizing human tissue factor in vitro by inhibiting the binding of TF factor/Vlla complex to factor X. The inhibition rate increase with the concentration. The pharmacodynamic and pharmacokinetic activity of this antibody was studied in vivo in rat models (CN101423552).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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