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Mfg Part Number

Ab03462-10.29

Vector Labs Ab03462-10.29 Anti-Tissue factor [ATR-5], Human Fab fragment, His-Tagged, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing 5 weeks old male BALB/c mice subcutaneously into the abdomen with purified human tissue factor in equal quantity of Freund's complete adjuvant.

$692.90

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Description

Product Class: Purified
Clone ID: ATR-5
Heavy Chain Modification: His-Tagged
Synonyms: CD142; TF; hTF; F3; Coagulation factor III; Thromboplastin; platelet tissue factor; factor III
Amount: 100 μg
Application Codes Clone: ELISA; Neutralize; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody binds human tissue factor (TF) a hemostatic protein which is involved in the extrinsic pathway of coagulation. TF is receptor for circulating serine protease factor VIIa, activating the catalytic VIIa protease domain. The complex formed functions to activate the zymogen factor X into activated factor Xa, which then catalyzes the formation of Prothrombin to Thrombin. The pathways results in a fibrin clot which acts to stop bleeding. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Application Notes: The binding of this antibody to human tissue factor expressed on the surface of human bladder carcinoma cells J82 was done using whole cell ELISA. This neutralizing activity of this antibody against the FX-binding was measured using the human placenta-derived thromboplastin. This antibody was also capable of inhibiting plasma coagulation (US6677436).

Product Class:	Purified
Clone ID:	ATR-5
Heavy Chain Modification:	His-Tagged
Synonyms:	CD142; TF; hTF; F3; Coagulation factor III; Thromboplastin; platelet tissue factor; factor III
Amount:	100 μg
Application Codes Clone:	ELISA; Neutralize; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody binds human tissue factor (TF) a hemostatic protein which is involved in the extrinsic pathway of coagulation. TF is receptor for circulating serine protease factor VIIa, activating the catalytic VIIa protease domain. The complex formed functions to activate the zymogen factor X into activated factor Xa, which then catalyzes the formation of Prothrombin to Thrombin. The pathways results in a fibrin clot which acts to stop bleeding. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Application Notes:	The binding of this antibody to human tissue factor expressed on the surface of human bladder carcinoma cells J82 was done using whole cell ELISA. This neutralizing activity of this antibody against the FX-binding was measured using the human placenta-derived thromboplastin. This antibody was also capable of inhibiting plasma coagulation (US6677436).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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