Mfg Part Number
Ab03473-10.3
Vector Labs Ab03473-10.3 Anti-Protein C [IgG1-7], Human IgG1, Fc Silent™, kappa (100 μg)
Quick Overview
The original antibody was generated from the original mouse antibody HPC-4 by performing site directed mutagenesis, consensus and resurfacing methods.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | IgG1-7 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | PROC; Vitamin K-dependent protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; HPC-4; HPC4; Fab-7 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; Blocking; Purification |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody specifically recognizes and binds the ProC epitope tag comprising the amino acid sequence 'EDQVDPRLIDGK'. This antibody binds the zymogen form of human Protein C in the activation peptide (spanning the thrombin cleavage site) and blocks protein C activation by thrombin–thrombomodulin both in vitro and in vivo. It does not react with activated protein C. |
| Application Notes: | This antibody is the humanized version of anti-Protein C antibody HPC-4. The binding of this antibody to protein C is calcium dependent. This humanized anti-protein C antibody exhibited calcium dependent binding which was significantly increased over that of the murine antibody HPC-4. The binding characterization of this antibody was performed using ELISA (PMID: 9680194). This antibody can be used to purify protein tagged with this 'EDQVDPRLIDGK' epitope. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |