Mfg Part Number
Ab03507-10.0
Vector Labs Ab03507-10.0 Anti-Glycoprotein Ilb/IIIa [SE], Human IgG1, lambda (100 μg)
Quick Overview
The original antibody was generated by screening human scFv antibody libraries.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | SE |
| Synonyms: | GPIIb/IIIa; CD41/CD61; integrin allb83 |
| Amount: | 100 μg |
| Application Codes Clone: | FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds the glycoprotein GPIIb/IIIa complex (CD41/CD61 complex). The GPIIb/IIIa is a heterodimeric complex formed after synthesis of one lib and one Ilia subunit. The principal ligand for GPIIb/IIIa is fibrinogen, but it also binds to fibronectin, von Willebrand factor, vitronectin, thrombospondin and CD40 ligand. The binding between GPIIb/IIIa and fibrinogen dimers leads to platelet aggregation and thrombus formation, and this is possible only when the receptor adopts its activated conformation. |
| Application Notes: | The antibody bound to activated platelets and inhibited platelet activation. This antibody was used for detection of activated platelets by flow cytometry (WO2020237304). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |