Mfg Part Number
Ab03510-1.1
Vector Labs Ab03510-1.1 Anti-LAG-3 [Ab8438], Mouse IgG1, kappa (100 μg)
Quick Overview
Vector Labs Ab03510-1.1 Anti-LAG-3 [Ab8438], Mouse IgG1, kappa (100 μg)
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | Ab8438 |
| Synonyms: | CD223; LAG3; FDC; Lymphocyte activation gene 3 protein |
| Amount: | 100 μg |
| Application Codes Clone: | SPR; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG4 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG4 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | The antibody is specific for human LAG-3. The antibody cross-reacts with cynomolgus LAG-3. The antibody does not cross react with murine LAG-3. |
| Application Notes: | The antibody is a humanized version of the mouse antibody mab84c. The humanized antibody could bind to hLAG-3+ cells, with an EC50 value that does not exceed 1.5nM. The humanized antibody prevented the binding activity of human LAG-3 and Daudi cells. The binding affinity of the humanized antibody was measured by surface plasmon resonance (Kd= 0.71 nM). The antibody was employed to design bispecific antibodies against LAG-3 and PD-L1, which antibody retained the binding activity to dual-target LAG3 and PD-1. Further, both the combination of the antibody and PD-1 antibody and the bispecific LAG-3 and PD-L1 antibody showed a good tumour inhibition effect in in vivo application (CN111848794). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |