Mfg Part Number
Ab03517-30.11
Vector Labs Ab03517-30.11 Anti-VACV [SC212], scFv fragment (His), ScFv, (50 μg)
Quick Overview
A phage display library of human single chain variable fragment (scFv) antibodies was constructed from the B cells of healthy volunteers boosted by the VACV vaccine. Human scFv was isolated by panning against VACV.
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| Product Class: | Purified |
|---|---|
| Clone ID: | SC212 |
| Heavy Chain Modification: | ScFv |
| Synonyms: | VV |
| Amount: | 50 μg |
| Application Codes Clone: | ELISA; in vitro neutralization |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | The antibody is specific for VACV. |
| Application Notes: | The scFv fragment was converted to human IgG1 (VC212). The binding affinity of VC212 was estimated by competition ELISA to IC50 values 22 µg/ml (146.67 nM). The humanized version of the antibody neutralized the VACV, as evidenced by the plaque reduction neutralization test result with a PRNT50 of ~0.16 mg/ml (~1.07 µM) (Shin et al., 2019; PMID: 30856707). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |