Mfg Part Number
Ab03572-1.159
Vector Labs Ab03572-1.159 Anti-DLL3 [HP-92], Mouse IgG1-Fc Fusion, (100 μg)
Quick Overview
The original antibody was generated by immunizing two alpacas with human DLL3.
$692.90
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| Product Class: | Purified |
|---|---|
| Clone ID: | HP-92 |
| Synonyms: | Delta-like protein 3; Drosophila Delta homolog 3 (Delta3) |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | VHH |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Alpaca VHH format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human Delta-like protein 3 (DLL3), which is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. Mature human DLL3 consists of a 466 amino acid (aa) extracellular domain (ECD) with one DSL domain and six EGF-like repeats, a 21 aa transmembrane segment, and a 105 aa cytoplasmic domain. It is an inhibitory Notch ligand that is highly expressed in small cell lung cancer (SCLC) and other neuroendocrine tumors but minimally expressed in normal tissues. It is therefore being explored as a potential therapeutic target in SCLC. |
| Application Notes: | The binding affinity to human DLL3 that is comparable with Rovalpituzumab. The binding characterization of this antibody for human DLL3 was done using ELISA. This antibody was capable of binding DLL3 expressed on the surface of H446 and H524 small cell lung cancer cell lines using flow cytometry (CN114057880). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |