Vector Labs Ab03573-23.0 Anti-DLL3 [SC16.13], Rabbit IgG, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: SC16.13
Synonyms: Delta-like protein 3; Drosophila Delta homolog 3 (Delta3)
Amount: 100 μg
Application Codes Clone: ELISA; FC; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds human DLL3 in the EGF2 domain. It does not cross-react with monkey/mouse/rat DLL3. Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. Mature human DLL3 consists of a 466 amino acid (aa) extracellular domain (ECD) with one DSL domain and six EGF-like repeats, a 21 aa transmembrane segment, and a 105 aa cytoplasmic domain. It is an inhibitory Notch ligand that is highly expressed in small cell lung cancer (SCLC) and other neuroendocrine tumors but minimally expressed in normal tissues. It is therefore being explored as a potential therapeutic target in SCLC.
Application Notes: The binding characterization of this antibody to human DLL3 was done using ELISA. Binding affinity of mouse IgG antibody for human DLL3 is 0.3 nM. This antibody can bind human DLL3 expressed on surface of 293 cells via flow cytometry. This antibody can mediate killing of tumor cells expressing DLL3. This antibody was covalently conjugated to PBD cytotoxic agent and the resulting ADCs resulted in tumor growth suppression lasting as long as 20 days. Humanized version is also available and drug conjugations made using the humanized versions also resulted in tumor suppression (US9089615).

Product Class:	Purified
Clone ID:	SC16.13
Synonyms:	Delta-like protein 3; Drosophila Delta homolog 3 (Delta3)
Amount:	100 μg
Application Codes Clone:	ELISA; FC; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds human DLL3 in the EGF2 domain. It does not cross-react with monkey/mouse/rat DLL3. Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. Mature human DLL3 consists of a 466 amino acid (aa) extracellular domain (ECD) with one DSL domain and six EGF-like repeats, a 21 aa transmembrane segment, and a 105 aa cytoplasmic domain. It is an inhibitory Notch ligand that is highly expressed in small cell lung cancer (SCLC) and other neuroendocrine tumors but minimally expressed in normal tissues. It is therefore being explored as a potential therapeutic target in SCLC.
Application Notes:	The binding characterization of this antibody to human DLL3 was done using ELISA. Binding affinity of mouse IgG antibody for human DLL3 is 0.3 nM. This antibody can bind human DLL3 expressed on surface of 293 cells via flow cytometry. This antibody can mediate killing of tumor cells expressing DLL3. This antibody was covalently conjugated to PBD cytotoxic agent and the resulting ADCs resulted in tumor growth suppression lasting as long as 20 days. Humanized version is also available and drug conjugations made using the humanized versions also resulted in tumor suppression (US9089615).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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