Vector Labs Ab03624-10.0 Anti-c-erbB2 [520C9], Human IgG1, kappa (100 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 520C9
Synonyms: Breast cancer cells; CD340; Receptor tyrosine-protein kinase erbB-2; Neu; HER2; MLN19; Metastatic lymph node gene 19 protein; p185erbB2
Amount: 100 μg
Application Codes Clone: IP; in vivo; IHC; IF; therapeutic
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: The antibody binds an approximately 200 kD protein found in cancerous breast tissue which has been identified as c-erbB-2.
Application Notes: The antibody stained breast tumors and breast cancer lines (Ring et al., 1989; PMID: 2470501). The antibody was employed in immunocytochemical assay to identify breast tumor cells (Franklin et al., 1996; PMID: 8932871). Fab fragment of the antibody was generated and tested for in vivo efficacy in the MX-1human breast tumor cell, where it showed a significant decrease in tumor volume (US5169774A). Immunoprecipitation tests on the antibody indicated that it bound to a monomeric c.a. 210,000 Da protein found in cancerous breast tissue with high association constant (US6054561A). The antibody was further evaluated for range breast cancer recognition by cell line immunofluorescence assays. The antibody showed positive results on SKBr3, BT483, CAMA1 (US5629197A). The antibody was employed in bi-specific and tri-specific antibody development to detect c-erbB2 expression and breast cancer treatment (Press et al. 2005; PMID: 16166438). Furthermore, it was employed in developing tri-functional antibody ertumaxomab for breast cancer patients (Jager et al. 2009; PMID: 19435924).

Product Class:	Purified
Clone ID:	520C9
Synonyms:	Breast cancer cells; CD340; Receptor tyrosine-protein kinase erbB-2; Neu; HER2; MLN19; Metastatic lymph node gene 19 protein; p185erbB2
Amount:	100 μg
Application Codes Clone:	IP; in vivo; IHC; IF; therapeutic
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	The antibody binds an approximately 200 kD protein found in cancerous breast tissue which has been identified as c-erbB-2.
Application Notes:	The antibody stained breast tumors and breast cancer lines (Ring et al., 1989; PMID: 2470501). The antibody was employed in immunocytochemical assay to identify breast tumor cells (Franklin et al., 1996; PMID: 8932871). Fab fragment of the antibody was generated and tested for in vivo efficacy in the MX-1human breast tumor cell, where it showed a significant decrease in tumor volume (US5169774A). Immunoprecipitation tests on the antibody indicated that it bound to a monomeric c.a. 210,000 Da protein found in cancerous breast tissue with high association constant (US6054561A). The antibody was further evaluated for range breast cancer recognition by cell line immunofluorescence assays. The antibody showed positive results on SKBr3, BT483, CAMA1 (US5629197A). The antibody was employed in bi-specific and tri-specific antibody development to detect c-erbB2 expression and breast cancer treatment (Press et al. 2005; PMID: 16166438). Furthermore, it was employed in developing tri-functional antibody ertumaxomab for breast cancer patients (Jager et al. 2009; PMID: 19435924).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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