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Mfg Part Number

Ab03638-1.159

Vector Labs Ab03638-1.159 Anti-S protein (RBD) [1E2], Mouse IgG1-Fc Fusion, (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated from a panel of humanized single domain antibodies derived from a synthetic library. The antibody was isolated by panning against SARS-CoV-2 spike receptor-binding domain (RBD).

$692.90

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Description

Product Class: Purified
Clone ID: 1E2
Synonyms: SARS CoV 2 S glycoprotein; COVID-19 Spike protein; RBD; Receptor Binding Domain; E2 glycoprotein; E2; Human coronavirus 2 spike glycoprotein; Peplomer protein; S glycoprotein; SARS coronavirus 2 S protein; SARS coronavirus 2 Spike Protein; SARS CoV 2 Spike protein; SARS CoV 2; SARS-CoV-2 S protein; SARSCoV2; SARS-COV-2 S protein; SARS-COV-2 Spike glycoprotein; SARSCOV2 Spike protein; Severe acute respiratory syndrome 2 spike glycoprotein; Severe acute respiratory syndrome virus 2 spike glycoprotein; Spike glycoprotein; 2019-nCoV; SARS-CoV2
Amount: 100 μg
Application Codes Clone: ELISA; SPR; neutralizing
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: VHH
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: The antibody binds to the RBD of the Spike protein of SARS-CoV.
Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis. The binding affinity of the VHH fragment to SARS-CoV-2 RBD was measured by surface plasmon resonance (Kd= 35.5 nM). The VHH showed half maximal neutralization concentration (EC50) of 0.069 µg/mL and 0.2401 µg/mL against SARS-CoV-2 pseudotypes, and authentic SARS-CoV-2, respectively. Fusion of the human IgG1 Fc to the VHH improved the neutralizing activity compared to the original format of the antibody. The Fc-fused VHH demonstrated potency with EC50 of 0.538 nM. (Chi et al, 2020; pmid: 32913273)

Product Class:	Purified
Clone ID:	1E2
Synonyms:	SARS CoV 2 S glycoprotein; COVID-19 Spike protein; RBD; Receptor Binding Domain; E2 glycoprotein; E2; Human coronavirus 2 spike glycoprotein; Peplomer protein; S glycoprotein; SARS coronavirus 2 S protein; SARS coronavirus 2 Spike Protein; SARS CoV 2 Spike protein; SARS CoV 2; SARS-CoV-2 S protein; SARSCoV2; SARS-COV-2 S protein; SARS-COV-2 Spike glycoprotein; SARSCOV2 Spike protein; Severe acute respiratory syndrome 2 spike glycoprotein; Severe acute respiratory syndrome virus 2 spike glycoprotein; Spike glycoprotein; 2019-nCoV; SARS-CoV2
Amount:	100 μg
Application Codes Clone:	ELISA; SPR; neutralizing
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	VHH
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	The antibody binds to the RBD of the Spike protein of SARS-CoV.
Application Notes:	The specificity of the original format of the antibody was confirmed by ELISA analysis. The binding affinity of the VHH fragment to SARS-CoV-2 RBD was measured by surface plasmon resonance (Kd= 35.5 nM). The VHH showed half maximal neutralization concentration (EC50) of 0.069 µg/mL and 0.2401 µg/mL against SARS-CoV-2 pseudotypes, and authentic SARS-CoV-2, respectively. Fusion of the human IgG1 Fc to the VHH improved the neutralizing activity compared to the original format of the antibody. The Fc-fused VHH demonstrated potency with EC50 of 0.538 nM. (Chi et al, 2020; pmid: 32913273)

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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