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Mfg Part Number

Ab03651-3.0

Vector Labs Ab03651-3.0 Anti-IL-33 [W3759-cAb1], Mouse IgG2b, kappa (100 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by using human IL-33 as an immunogen.

$570.70

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Description

Product Class: Purified
Clone ID: W3759-cAb1
Synonyms: Interleukin-33; C9orf26; IL1F11; NFHEV; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV; W3759-cAb1-sz10-p1-xIgG4K.SP
Amount: 100 μg
Application Codes Clone: ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG4
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds an epitope between amino acid residues Ser112-Thr270 of the human IL-33. Interleukin 33 (IL-33). Interleukin 33 (IL-33) is a multifunctional cytokine which is constitutively expressed in structural cells such as smooth muscle cells, fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, epithelial cells, and endothelial cells. It is involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines like IL-4, IL-5 and IL-13. It is also involved in activation of mast cells, basophils, eosinophils and natural killer cells. A study found that IL-33 is a bifunctional protein. On the one hand, IL-33 is localized in the nucleus and acts as a transcription factor; on the other hand, IL-33 is secreted outside the cell and acts as a cytokine by interacting with its receptor ST2.
Application Notes: This antibody binds human IL-33 with a high binding affinity of 0.776 pM. The binding characterization of this antibody was done using ELISA and SPR (CN111620948).

Product Class:	Purified
Clone ID:	W3759-cAb1
Synonyms:	Interleukin-33; C9orf26; IL1F11; NFHEV; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV; W3759-cAb1-sz10-p1-xIgG4K.SP
Amount:	100 μg
Application Codes Clone:	ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG4
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds an epitope between amino acid residues Ser112-Thr270 of the human IL-33. Interleukin 33 (IL-33). Interleukin 33 (IL-33) is a multifunctional cytokine which is constitutively expressed in structural cells such as smooth muscle cells, fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, epithelial cells, and endothelial cells. It is involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines like IL-4, IL-5 and IL-13. It is also involved in activation of mast cells, basophils, eosinophils and natural killer cells. A study found that IL-33 is a bifunctional protein. On the one hand, IL-33 is localized in the nucleus and acts as a transcription factor; on the other hand, IL-33 is secreted outside the cell and acts as a cytokine by interacting with its receptor ST2.
Application Notes:	This antibody binds human IL-33 with a high binding affinity of 0.776 pM. The binding characterization of this antibody was done using ELISA and SPR (CN111620948).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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